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NSMCE2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA836260LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NSMCE2 Polyclonal antibody
Uniprot No.
Q96MF7
Target Names
NSMCE2
Alternative Names
C8orf36 antibody; E3 SUMO-protein ligase NSE2 antibody; hMMS21 antibody; hNSE2 antibody; methyl methanesulfonate sensitivity gene 21 antibody; MMS21 antibody; MMS21 homolog antibody; non-SMC element 2 antibody; Non-SMC element 2 homolog antibody; Non-structural maintenance of chromosomes element 2 homolog antibody; NSE2 antibody; NSE2_HUMAN antibody; Nsmce2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 SUMO-protein ligase NSE2 protein (1-247AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
Gene References into Functions
  1. Absence of NSMCE2 affects survival upon topoisomerase II inhibitor etoposide-induced DNA double-strand breaks double-strand breaks. PMID: 27792189
  2. our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia. PMID: 25245984
  3. support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress PMID: 25105364
  4. show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1 PMID: 22751501
  5. Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex. PMID: 21550342
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20460480
  8. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells PMID: 16055714
  9. MMS21 dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression and that this function appears to be independent of SMC6. PMID: 19502785
  10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19549807
  11. Observational study of gene-disease association. (HuGE Navigator) PMID: 18163389

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Involvement in disease
Seckel syndrome 10 (SCKL10)
Subcellular Location
Nucleus. Chromosome, telomere. Nucleus, PML body.
Protein Families
NSE2 family
Database Links

HGNC: 26513

OMIM: 617246

KEGG: hsa:286053

STRING: 9606.ENSP00000287437

UniGene: Hs.388297

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